IRVING C. SHERMAN, M.D.
In a recent study of the effect of tetraethylammonium chloride on the course of multiple sclerosis, there became available for analysis a group of patients who were examined on repeated occasions. These patients frequently showed a variability in objective signs which at first was thought due to the treatment. However, careful study, as reported elsewhere,1 revealed that actually the treatment had no effect on the course of the disease.
If a drug is efficacious in the treatment of multiple sclerosis, then the majority of the pathologic signs should show amelioration. Actually it was found that, although a certain number of
SHERMAN IC. VARIABILITY OF SIGNS IN MULTIPLE SCLEROSIS(VARIABILITY OF SIGNS IN MULTIPLE SCLEROSIS*). Ann Intern Med. 1951;35:1329–1335. doi: 10.7326/0003-4819-35-6-1329
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Published: Ann Intern Med. 1951;35(6):1329-1335.
Multiple Sclerosis, Neurology.
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