A. I. LANSING
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Arteriosclerosis is currently believed to be a metabolic disorder, a disturbance of cholesterol metabolism which, by some obscure means, leads to accumulation of cholesterol in the lining of arteries. It is further proposed that aging is not a factor in the genesis of arteriosclerosis, since fatty plaques can be experimentally produced in some animals at any age.
This concept of arteriosclerosis is not entirely satisfying. It does not explain the fact that some plaques are entirely fibrous and do not contain cholesterol; it does not explain the focal nature of arteriosclerotic lesions, the greater severity of lesions in the abdominal
LANSING AI. THE RÔLE OF ELASTIC TISSUE IN THE FORMATION OF THE ARTERIOSCLEROTIC LESION1. Ann Intern Med. ;36:39–49. doi: 10.7326/0003-4819-36-1-39
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Published: Ann Intern Med. 1952;36(1):39-49.
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