N. E. ROSSETT, M.D., F.A.C.P.; F. H. KNOX JR., M.D.; S. L. STEPHENSON JR., M.D.
In two communicationsl1, 2 evaluating a number of commonly used antacids utilizing a continuous pH recorder in vivo and in vitro, Rossett and Flexner concluded that magnesium oxide, peroxide, hydroxide and carbonate, as well as calcium carbonate, when combined with an amphoteric substance such as milk or aluminum hydroxide gel, were efficiently buffered in their alkaline range preventing rebound and produced long-acting antacids. A promise of clinical evaluation of such antacids made at that time could not be effectively fulfilled because of World War II service and until the senior author had the opportunity of supervising a large gastrointestinal
ROSSETT NE, KNOX FH, STEPHENSON SL. PEPTIC ULCER: MEDICAL CURE BY EFFICIENT GASTRIC ACID NEUTRALIZATION(PEPTIC ULCER: MEDICAL CURE BY EFFICIENT GASTRIC ACID NEUTRALIZATION*). Ann Intern Med. 1952;36:98–109. doi: 10.7326/0003-4819-36-1-98
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Published: Ann Intern Med. 1952;36(1):98-109.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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