BERNARD M. NORCROSS, M.D., F.A.C.P.; L. MAXWELL LOCKIE, M.D., F.A.C.P.; ANTHONY G. CONSTANTINE, M.D.; JOHN H. TALBOTT, M.D., F.A.C.P.; ROBERT H. STEIN, M.D.
This investigation was intended to demonstrate any effect of Cortone and ACTH upon the histopathologic lesions of rheumatoid arthritis. In 1945, Freund, Steiner and their associates1, 2 described an inflammatory lesion of striated muscle in patients with rheumatoid arthritis. This lesion, consisting of a localized collection of lymphocytes, was widely distributed in the skeletal muscles, and was called "nodular polymyositis." The authors believed these lesions to be specific for rheumatoid arthritis, but other observers3-8 have demonstrated the presence of similar changes in a variety of disease states and even in normal individuals. Two reports deserve special attention in this respect.
NORCROSS BM, LOCKIE LM, CONSTANTINE AG, TALBOTT JH, STEIN RH. THE EFFECT OF CORTONE AND ACTH ON THE HISTOPATHOLOGIC LESIONS OF RHEUMATOID ARTHRITIS1. Ann Intern Med. ;36:751–764. doi: 10.7326/0003-4819-36-3-751
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Published: Ann Intern Med. 1952;36(3):751-764.
Rheumatoid Arthritis, Rheumatology.
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