MADELAINE RAY BROWN, F.A.C.P.
The toxin of the diphtheria bacillus offers the physician an unusual opportunity to observe the onset and march of signs in polyneuritis. The patient is in the hospital 10 days before the onset of palatal weakness and several weeks before the onset of paralysis of the limbs. Because the etiology of postdiphtheritic polyneuritis is known, a study of 53 such patients may shed light on the mechanism involved in 40 patients with a polyneuritis of unknown etiology but similar to the postdiphtheritic type in its clinical manifestations, spinal fluid and postmortem findings.
Since 1943, diphtheria has increased steadily in Boston,
BROWN MR. THE MECHANISM INVOLVED IN POLYNEURITIS AS EXEMPLIFIED BY POSTDIPHTHERITIC POLYNEURITIS1. Ann Intern Med. ;36:786–791. doi: 10.7326/0003-4819-36-3-786
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Published: Ann Intern Med. 1952;36(3):786-791.
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