RICHARD W. MAXWELL, M.D.; VIRGIL SCOTT, M.D.
With the simplification of treatment as the result of the demonstrated efficacy of penicillin, the major problem in clinical syphilis at the present time is the differentiation of positive serologic tests due to syphilis from those due to biologic false-positive reactions. The occurrence of "acute" or shortlived false-positive reactions following certain diseases and conditions such as malaria, infectious mononucleosis, viral pneumonia, smallpox vaccination and many others is well known. Ordinarily, false-positive reactions due to these causes revert spontaneously to negative in periods of days, weeks or, at most, a few months. In addition, it has long been suspected that "chronic"
MAXWELL RW, SCOTT V. THE PROVOCATIVE SEROLOGICAL REACTION IN LATE SYPHILIS: ITS RELATION TO TECHNICAL FACTORS1. Ann Intern Med. ;36:979–991. doi: 10.7326/0003-4819-36-4-979
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Published: Ann Intern Med. 1952;36(4):979-991.
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