CLAYTON E. WHEELER; ARTHUR C. CURTIS, F.A.C.P.; EDWARD P. CAWLEY; ROBERT H. GREKIN; BERTRAM ZHEUTLIN
Calcification is a process which results in the accumulation of lime salts in a tissue in amounts which are demonstrable on microscopic, roentgenographic and often on naked-eye examination. Normally this process involves only bones and teeth, and when any other tissue is the site of calcium deposition, pathologic calcification, or calcinosis, is said to exist. Although there has been much investigation of this subject, the exact mechanism is not known whereby demonstrable aggregates of the carbonate and phosphate of calcium are produced from invisible components present in blood and tissue fluid.
Normally the amount of calcium and phosphorus in
CLAYTON E. WHEELER, ARTHUR C. CURTIS, EDWARD P. CAWLEY, ROBERT H. GREKIN, BERTRAM ZHEUTLIN. SOFT TISSUE CALCIFICATION, WITH SPECIAL REFERENCE TO ITS OCCURRENCE IN THE "COLLAGEN DISEASES"(SOFT TISSUE CALCIFICATION, WITH SPECIAL REFERENCE TO ITS OCCURRENCE IN THE "COLLAGEN DISEASES"*). Ann Intern Med. 1952;36:1050–1075. doi: 10.7326/0003-4819-36-4-1050
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Published: Ann Intern Med. 1952;36(4):1050-1075.
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