RIVAS FEDERICO DIÉZ, M.D.; MORALES FEDERICO HERNÁNDEZ, M.D., F.A.C.P.; LEO M. MEYER, M.D.
Soon after the announcement in July, 1945, of the synthesis of Lactobacillus casei factor by several investigators1 at the Lederle Laboratories and the Calco Division of the American Cyanamid Company, it was shown by Spies, Vilter and Koch2 that this substance possessed a definite hematopoietic effect in patients with macrocytic anemia when administered intravenously, intramuscularly or orally.
In January, 1946, Spies, López, Menéndez, Minnich and Koch3 reported that the macrocytic anemia of tropical sprue found in Cuba responded in a similar manner. Several other investigators4, 5, 6, 7, 8, 10 also reported striking improvement of anemia when folic acid was
FEDERICO DIÉZ R, FEDERICO HERNÁNDEZ M, MEYER LM. THE ORAL USE OF COMBINED VITAMIN B12 AND FOLIC ACID IN TROPICAL SPRUE1. Ann Intern Med. 1952;36:1076–1085. doi: 10.7326/0003-4819-36-4-1076
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Published: Ann Intern Med. 1952;36(4):1076-1085.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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