JAMES J. CONN, M.D.; R. W. KISSANE, M.D., F.A.C.P.; RUTH A. KOONS, M.D., F.A.C.P.; THOMAS E. CLARK, M.D.
The potent vasodilator action of khellin,2 officially named visammin,1 has been demonstrated in many pharmacologic laboratories by means of the heart-lung preparation and other technics during the past two decades. Among the earlier studies were those carried out by Fahmy,2 Samaan3 and Spaeth and Gruber,4 while more recently Anrep, Barsoum and Kenawy5, 6, 7 have proved that khellin has a more powerful action than many of the coronary vasodilators commonly employed. Toxicity studies in animals have not been numerous, but Samaan3 found that the lethal dose in toads and rabbits was many times greater than the therapeutic dose, and the
CONN JJ, KISSANE RW, KOONS RA, CLARK TE. THE TREATMENT OF ANGINA PECTORIS WITH KHELLIN1: Part I. Ann Intern Med. 1952;36:1173–1178. doi: 10.7326/0003-4819-36-5-1173
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Published: Ann Intern Med. 1952;36(5):1173-1178.
Cardiology, Coronary Heart Disease.
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