EDWARD W. LOWMAN, M.D.; CHARLES H. SLOCUMB, M.D.
Since the initial report in 1935 by Baehr and associates1 of the diffuse peripheral vascular involvement in lupus erythematosus, much histologic investigation has been directed toward clarifying the nature and extent of this process. Initially it was the impression of these investigators that it was primarily a process of endothelial proliferation associated with narrowing and occlusion of small vessels. Subsequently, in 1941, Klemperer and his group of workers2 clarified this misconception, and introduced the concept of fibrinous degeneration. It was proposed that in lupus erythematosus, collagen diffusely underwent a degenerative change as a result of an "X" stimulus, and, because
LOWMAN EW, SLOCUMB CH. THE PERIPHERAL VASCULAR LESIONS OF LUPUS ERYTHEMATOSUS12. Ann Intern Med. ;36:1206–1216. doi: 10.7326/0003-4819-36-5-1206
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© 2018
Published: Ann Intern Med. 1952;36(5):1206-1216.
DOI: 10.7326/0003-4819-36-5-1206
Lupus Erythematosus, Rheumatology.
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