ARTHUR G. STEINBERG, Ph.D.; RUSSELL M. WILDER, M.D., Ph.D., F.A.C.P.
In the second edition of Darwin's The Variation of Animals and Plants Under Domestication,1 published in 1894, it is stated that the rule with respect to the age of onset of a hereditary disease in parent and child is inheritance at a corresponding period of life. It was noted, however, that "when the rule fails the disease is apt to come on earlier in the child than in the parent; the exceptions in the other direction being very much rarer." Nevertheless, investigators were finding frequent exceptions to the rule for many different diseases with a variable age of onset; and
STEINBERG AG, WILDER RM. AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUS1. Ann Intern Med. ;36:1285–1296. doi: 10.7326/0003-4819-36-5-1285
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Published: Ann Intern Med. 1952;36(5):1285-1296.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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