RICHARD B. HUNTER, M.D.; E. E. MUIRHEAD, M.D.
The separation of the clinical course of "lower nephron nephrosis"1 into three periods2, 3, 4 emphasizes not only the therapeutic indications of each period but also serves to indicate certain disturbances in renal function. Thus, in the first period (the period of renal damage), peripheral circulatory failure appears to be the most common antecedent cause of tubular damage,5, 6 and renal function suffers from the effects of shock.6 The second period (period of maximal renal insufficiency), lasting usually eight to 14 days, is characterized by failure to clear waste products and failure of regulation of water and electrolyte balance. These
HUNTER RB, MUIRHEAD EE. PROLONGED RENAL SALT WASTAGE IN "LOWER NEPHRON NEPHROSIS"1. Ann Intern Med. ;36:1297–1308. doi: 10.7326/0003-4819-36-5-1297
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Published: Ann Intern Med. 1952;36(5):1297-1308.
Acute Kidney Injury, Nephrology.
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