ROGER S. MITCHELL, M.D.; EMANUEL WOLINSKY, M.D.; WILLIAM STEENKEN JR.
The appearance of streptomycin-resistant tubercle bacilli in the sputum of streptomycin-treated patients with pulmonary tuberculosis has been repeatedly found to coincide with a loss of clinical effectiveness of the drug. Tubercle bacilli exhibiting streptomycin sensitivity, as well as others with different degrees of streptomycin resistance, have occasionally been recovered from one or more lesions in the same patient, both at post mortem,1-6 and from surgically resected lung tissue.1, 7 There is no published evidence to date that highly streptomycin-resistant tubercle bacilli may become streptomycin-sensitive after repeated in vitro passage in culture media both with and without streptomycin. Serial animal passage
MITCHELL RS, WOLINSKY E, STEENKEN W. THE RECOVERY OF STREPTOMYCIN-SENSITIVE TUBERCLE BACILLI FROM A PATIENT WITH PULMONARY TUBERCULOSIS WHO HAD PREVIOUSLY YIELDED HIGHLY RESISTANT BACILLI1. Ann Intern Med. ;36:1309–1317. doi: 10.7326/0003-4819-36-5-1309
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Published: Ann Intern Med. 1952;36(5):1309-1317.
Infectious Disease, Mycobacterial Infections, Pulmonary Tuberculosis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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