EDWIN A. CROST, M.D.; HERZL FRIEDLANDER, M.D.
In 1925, Bradbury and Eggleston1 reported a syndrome, previously undescribed in medical literature, characterized by a fall in blood pressure in the erect position or on exertion, slow, unchanging pulse, decreased sweating, diminished basal metabolic rate, intolerance to heat, increased reactivity to epinephrine, decreased reactivity to atropine, blood urea nitrogen at the upper limits of normal, and unchanging electrocardiogram during blood pressure drop.
The exact etiology of orthostatic hypotension has remained obscure, despite 40 or more case reports in the medical literature. The consensus favors a lesion in the central nervous system, probably located in the hypothalamus, which results in
CROST EA, FRIEDLANDER H. ORTHOSTATIC HYPOTENSION: REPORT OF A CASE REFRACTORY TO VASOCONSTRICTOR DRUGS; WITH OBSERVATIONS ON USE OF DESOXYCORTICOSTERONE, LNOREPINEPHRINE, ACTH AND VASOPRESSOR POTENTIATING SUBSTANCES(ORTHOSTATIC HYPOTENSION: REPORT OF A CASE REFRACTORY TO VASOCONSTRICTOR DRUGS; WITH OBSERVATIONS ON USE OF DESOXYCORTICOSTERONE, LNOREPINEPHRINE, ACTH AND VASOPRESSOR POTENTIATING SUBSTANCES*). Ann Intern Med. 1952;36:1343–1350. doi: 10.7326/0003-4819-36-5-1343
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Published: Ann Intern Med. 1952;36(5):1343-1350.
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