LEONARD WALLENSTEIN, M.D.; JEROME SNYDER, M.D.
In the few years since the isolation and synthesis of Chloromycetin, a profusion of reports has attested its value and wide chemotherapeutic range. It has also been attractive because of its non-toxic character and because it is equally satisfactory by oral and parenteral route.
Toxicity studies in animals and man have shown Chloromycetin to be practically free of both acute and chronic toxicity at levels well within the therapeutic range, even after administration over a long period. A single report1 of three cases (two typhoid and one acute brucellosis) treated with the drug records a significant fall in the number
WALLENSTEIN L, SNYDER J. NEUROTOXIC REACTION TO CHLOROMYCETIN1. Ann Intern Med. ;36:1526–1528. doi: 10.7326/0003-4819-36-6-1526
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Published: Ann Intern Med. 1952;36(6):1526-1528.
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