B. STANLEY COHEN, M.D.; LEO M. MEYER, M.D.; ROBERT FADEM, M.D.
The hematologic and clinical response of patients with macrocytic anemia to the administration of pteroylglutamic acid has been well established. Although folic acid does not represent a complete treatment for pernicious anemia, it has been found most useful in nutritional macrocytic anemia, megaloblastic anemia of infancy, macrocytic anemia of pregnancy and sprue.1, 2 Thymine (5-methyl uracil) has been found efficacious in the treatment of certain of the macrocytic anemias in relapse, notably pernicious anemia and sprue, when administered in doses bearing a ratio of 5,000:1 to the required dosage of folic acid.3, 4
More recently, the applications of vitamin
COHEN BS, MEYER LM, FADEM R. SPRUE REFRACTORY TO VITAMIN B12; SATISFACTORY RESPONSE TO FOLIC ACID1. Ann Intern Med. 1952;36:1533–1537. doi: 10.7326/0003-4819-36-6-1533
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Published: Ann Intern Med. 1952;36(6):1533-1537.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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