CAROLINE BEDELL THOMAS, M.D., F.A.C.P.
Although the thiocyanate compounds have been used as remedies for essential hypertension since early in the Twentieth Century, our incomplete knowledge of their mode of action, and the variability of the clinical response, have served to throw doubt upon their therapeutic value. Evidence is accumulating, however, that the thiocyanate ion may have a specific action upon some of the glands of internal secretion, including the adrenal cortex. In view of the recent interest concerning the rôle of the adrenal cortex in the pathogenesis of essential hypertension,1-7 it seems worth while to review what is already known, to present some
THOMAS CB. WHAT IS THE MODE OF ACTION OF THIOCYANATE COMPOUNDS IN ESSENTIAL HYPERTENSION?(WHAT IS THE MODE OF ACTION OF THIOCYANATE COMPOUNDS IN ESSENTIAL HYPERTENSION?*). Ann Intern Med. 1952;37:106–122. doi: 10.7326/0003-4819-37-1-106
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Published: Ann Intern Med. 1952;37(1):106-122.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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