S. W. HOOBLER, M.D., F.A.C.P.; R. W. CORLEY, M.D.; T. G. KABZA, M.D.; H. F. LOYKE, M.D.
Protoveratrine, a purified derivative of Veratrum album,1, 2 is superior to the alkaloids from Veratrum viride which have been used previously in the treatment of hypertension in that, in a carefully adjusted dosage schedule, the blood pressure can be reduced for six to eight hours daily without producing nausea, vomiting or tolerance to the medication. Such temporary remissions in blood pressure are of a magnitude and duration sufficient to afford real relief to the heart and arteries of the hypertensive patient. We have reported elsewhere3, 4 that parenteral administration of protoveratrine is accompanied by a decline in resistance to blood
HOOBLER SW, CORLEY RW, KABZA TG, LOYKE HF. TREATMENT OF HYPERTENSION WITH ORAL PROTOVERATRINE1. Ann Intern Med. ;37:465–481. doi: 10.7326/0003-4819-37-3-465
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Published: Ann Intern Med. 1952;37(3):465-481.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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