THOMAS J. MCGURL JR., M.D.
Periarteritis nodosa continues to be a disease of unknown etiology with protean manifestations for which there is no known specific therapy. Many causes of this disease have been postulated, including sensitization to serums, drugs, infections, etc. However, no factor common to all cases has been found.1, 2 It is characterized by an inflammatory, necrotizing reaction in the walls of small arteries and arterioles, the earliest stage of which consists of a period of hyaline degeneration of the media. This is followed by infiltration of the coats with polymorphonuclears, eosinophils, lymphocytes and plasma cells. Later there is fibroblastic proliferation, with partial
MCGURL TJ. PERIARTERITIS NODOSA: REPORT OF A CASE TREATED WITH PARA-AMINOBENZOIC ACID1. Ann Intern Med. 1952;37:606–611. doi: 10.7326/0003-4819-37-3-606
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Published: Ann Intern Med. 1952;37(3):606-611.
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