EVERETT H. SANNEMAN JR., M.D.; MARION F. BEARD, A.B., M.D., F.A.C.P.
The simultaneous discovery of vitamin B12 by Rickes and his co-workers1 and by Smith2 was soon followed by numerous clinical reports3, 4, 5, 6 of its efficacy in treating pernicious anemia in relapse. Many reports, particularly those of Ungley3 and Meacham et al.,9 suggested that it was equally effective as a maintenance therapy. Our group,7 however, has reported that in certain instances vitamin B12 alone is not a complete maintenance therapy, and the data suggested that some additional factor was necessary. Meyer10 has reported on the effectiveness of a combination of folic acid and vitamin B12 orally. Bethell11 and
SANNEMAN EH, BEARD MF. PARENTERAL B12-FOLIC ACID THERAPY IN PERNICIOUS ANEMIA1. Ann Intern Med. ;37:755–760. doi: 10.7326/0003-4819-37-4-755
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Published: Ann Intern Med. 1952;37(4):755-760.
Hematology/Oncology, Red Cell Disorders.
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