P. W. C.
Both the etiology and the therapeutic management of ulcerative colitis present many unsolved problems, and additional information bearing on this subject is badly needed. Recent observations indicating a relationship of lysozyme to this disease naturally have aroused much interest.
Lysozyme is a mucolytic and bacteriolytic enzyme (or rather a group of enzymes), first isolated and described by Fleming in egg white, and also in human tears and other secretions. Lysozyme is a crystallizable basic protein of relatively low molecular weight, optimally active at a pH of about 6.0. It causes hydrolysis of certain mucopolysaccharides, and it can be titrated by
C. PW. LYSOZYME IN ULCERATIVE COLITIS. Ann Intern Med. ;37:813–816. doi: 10.7326/0003-4819-37-4-813
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Published: Ann Intern Med. 1952;37(4):813-816.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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