JOHN M. BUTTERLY, M.D.; LOUIS FISHMAN, M.D.; JULES SECKLER, M.D.; HERMAN STEINBERG, M.D.
Since Addison's classic and comprehensive description of the disease bearing his name,1, 2 accepted etiologic factors have included tuberculosis and cytotoxic contracted adrenals (atrophy) almost exclusively. Much less frequently, the disease has been ascribed to amyloidosis, fatty degeneration, syphilis, tumors, vascular lesions and trauma of the adrenals. Both glands are involved completely and extensively in almost all cases, although rare cases with unilateral destruction or aplasia have been reported.3
A complete review of the literature reflects the widespread doubt cast on the mechanism of neoplastic destruction of the adrenals, more specifically by metastatic involvement, as a cause of adrenal cortical
BUTTERLY JM, FISHMAN L, SECKLER J, STEINBERG H. ADDISON'S DISEASE SECONDARY TO METASTATIC CARCINOMA OF THE ADRENAL GLANDS1. Ann Intern Med. ;37:930–939. doi: 10.7326/0003-4819-37-5-930
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Published: Ann Intern Med. 1952;37(5):930-939.
Adrenal Disorders, Endocrine and Metabolism, Hematology/Oncology.
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