GEORGE W. THORN, F.A.C.P.; J. HARTWELL HARRISON; JOHN P. MERRILL; MODESTINO G. CRISCITIELLO; THOMAS F. FRAWLEY; JOHN T. FINKENSTAEDT
The aggravation of hypertensive cardiovascular disease which follows ACTH administration1, 2 lends support to the concept that amelioration of the vascular disease might follow a critical reduction in the function of the adrenal cortex. Further evidence in support of the thesis that the adrenal cortical secretions are involved in the maintenance of hypertension has been presented in another publication by one of us.3
The importance of the salt-retaining adrenal hormones in maintaining hypertension is suggested by the authors' experience in the treatment of hypertensive patients who subsequently have developed Addison's disease (figures 1 and 2). Under these circumstances a
THORN GW, HARRISON JH, MERRILL JP, CRISCITIELLO MG, FRAWLEY TF, FINKENSTAEDT JT. CLINICAL STUDIES ON BILATERAL COMPLETE ADRENALECTOMY IN PATIENTS WITH SEVERE HYPERTENSIVE VASCULAR DISEASE1. Ann Intern Med. ;37:972–1005. doi: 10.7326/0003-4819-37-5-972
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Published: Ann Intern Med. 1952;37(5):972-1005.
Adrenal Disorders, Cardiology, Coronary Risk Factors, Endocrine and Metabolism, Hypertension.
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