DAVID T. SMITH, M.D., F.A.C.P.
Evidence is accumulating to show that the complex balance which exists among microörganisms constituting the normal flora of the body is disturbed by the prolonged administration of the newer antibiotics. This may result in the development of secondary vitamin deficiencies or the evolution of new infectious disease syndromes.
The importance of the normal microbiologic flora in man was not appreciated until it was disorganized by the administration of the newer antibiotics. The basic phenomenon is not new, and biologists dealing with parasitic diseases of plants are familiar with the importance of the normal flora of the soil and its influence
SMITH DT. THE DISTURBANCE OF THE NORMAL BACTERIAL ECOLOGY BY THE ADMINISTRATION OF ANTIBIOTICS WITH THE DEVELOPMENT OF NEW CLINICAL SYNDROMES1. Ann Intern Med. ;37:1135–1143. doi: 10.7326/0003-4819-37-6-1135
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Published: Ann Intern Med. 1952;37(6):1135-1143.
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