THOMAS C. GUTHRIE, M.D.; J. F. KURTZKE, M.D.; LOUIS BERLIN, M.D.
The manifestations of acute multiple sclerosis are often fulminating and massively incapacitating but are also likely to subside completely.1 In some instances the illness may lead rapidly to death, although the fatal episode may have been preceded by lesser attacks which have subsided.2
Several authors have described in considerable clinical detail acute, fatal attacks of multiple sclerosis.3 The patients discussed have rapidly developed quadriplegia or bulbar dysfunctions or both prior to death. Occasionally they have been observed to be dyspneic or to evidence Cheyne-Stokes respiration. One author has made the undocumented statement that a patient with acute multiple sclerosis may
GUTHRIE TC, KURTZKE JF, BERLIN L. ACUTE RESPIRATORY FAILURE IN MULTIPLE SCLEROSIS AND ITS MANAGEMENT1. Ann Intern Med. 1952;37:1197–1203. doi: 10.7326/0003-4819-37-6-1197
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Published: Ann Intern Med. 1952;37(6):1197-1203.
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