H. F. FRASER, M.D.; HARRIS ISBELL, M.D., F.A.C.P.
Recently considerable interest has been expressed in the possible ameliorating effects of cortisone and adrenocorticotropic hormone of the anterior pituitary on the symptoms of withdrawal of morphine and related drugs from addicted persons. Rowe1 and co-workers have reported that ACTH and cortisone relieved symptoms of abstinence from meperidine (Demerol). Boswell2 reported beneficial results with cortisone in combined addiction to meperidine and morphine. Hogness3 found that intravenous infusions of ACTH reduced or abolished withdrawal symptoms in 12 of 19 patients presumed to be addicted to heroin. On the other hand, Thorn4 and co-workers attempted to withdraw narcotics in one case of
FRASER HF, ISBELL H. FAILURE OF CORTISONE AND ACTH IN TREATMENT OF THE MORPHINE ABSTINENCE SYNDROME1. Ann Intern Med. ;38:234–238. doi: 10.7326/0003-4819-38-2-234
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Published: Ann Intern Med. 1953;38(2):234-238.
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