ALVIN SLIPYAN, M.D.
The search for a chemotherapeutic agent in leukemia is still in progress. This drug should have a wide margin of safety, and be very effective and easy to administer. The most recent of the drugs tried clinically is triethylene melamine.
As far back as 1946, when the nitrogen mustards were introduced into medical practice for the palliative treatment of the lymphomas, leukemias, etc. by Rhodes1 and a host of other investigators reporting in various journals, work had already begun to improve this form of therapy. Changing the structural formula of the mustards for new drugs was a logical sequence. Lewis
SLIPYAN A. UNUSUAL TOXICITY TO TRIETHYLENE MELAMINE IN A CASE OF CHRONIC MYELOGENOUS LEUKEMIA1. Ann Intern Med. ;38:331–335. doi: 10.7326/0003-4819-38-2-331
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Published: Ann Intern Med. 1953;38(2):331-335.
Emergency Medicine, Hematology/Oncology, Leukemia/Lymphoma.
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