WILLIAM J. HARRINGTON, M.D.; CHARLES C. SPRAGUE, M.D.; VIRGINIA MINNICH, M.S.; CARL V. MOORE, M.D., F.A.C.P.; ROBERT C. AULVIN, B.S.; REUBENIA DUBACH, Ph.D.
The mechanisms responsible for the low platelet count in idiopathic thrombocytopenic purpura are not well understood despite the careful studies by many competent investigators. The thrombocytopenia has been attributed to:
1. A decrease in the rate of platelet formation from megakaryocytes1, 2 because of splenic inhibition of these cells;3, 4, 5, 6
2. An increase in the rate of platelet destruction by the spleen,7, 8, 9, 10, 11, 12 and
3. A combination of damage to both megakaryocytes and circulating platelets.13, 14
Evidence to support the latter concept has been presented recently. A thrombocytopenic factor which damages circulating platelets and
WILLIAM J. HARRINGTON, CHARLES C. SPRAGUE, VIRGINIA MINNICH, CARL V. MOORE, ROBERT C. AULVIN, REUBENIA DUBACH. IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA(IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA*). Ann Intern Med. 1953;38:433–469. doi: 10.7326/0003-4819-38-3-433
Download citation file:
Published: Ann Intern Med. 1953;38(3):433-469.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use