WILLIAM J. HARRINGTON, M.D.; CHARLES C. SPRAGUE, M.D.; VIRGINIA MINNICH, M.S.; CARL V. MOORE, M.D., F.A.C.P.; ROBERT C. AULVIN, B.S.; REUBENIA DUBACH, Ph.D.
The mechanisms responsible for the low platelet count in idiopathic thrombocytopenic purpura are not well understood despite the careful studies by many competent investigators. The thrombocytopenia has been attributed to:
1. A decrease in the rate of platelet formation from megakaryocytes1, 2 because of splenic inhibition of these cells;3, 4, 5, 6
2. An increase in the rate of platelet destruction by the spleen,7, 8, 9, 10, 11, 12 and
3. A combination of damage to both megakaryocytes and circulating platelets.13, 14
Evidence to support the latter concept has been presented recently. A thrombocytopenic factor which damages circulating platelets and
HARRINGTON WJ, SPRAGUE CC, MINNICH V, MOORE CV, AULVIN RC, DUBACH R. IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA1. Ann Intern Med. ;38:433–469. doi: 10.7326/0003-4819-38-3-433
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Published: Ann Intern Med. 1953;38(3):433-469.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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