JOHN S. GILSON, M.D.; CECIL M. DAY, M.D.
The cause of the pain in angina pectoris and in myocardial infarction has been considered by most observers to be myocardial ischemia and consequent abnormal metabolism due to lack of oxygen or accumulated metabolites.1, 2 Some have postulated distention of vessels proximal to the obstruction as a cause of pain,3 and others, distention of the infarcted area of myocardium with each heart beat.4 The cases herein described support the concept of ischemia and its consequences as the cause of pain. They also give electrocardiographic support to and explanation of the syndrome of premonitory pain in coronary thrombosis described by Feil.5
GILSON JS, DAY CM. OBSERVATIONS ON THE RELATIONSHIP OF PAIN TO THE PROCESS OF MYOCARDIAL INFARCTION, AS SHOWN BY ELECTROCARDIOGRAPHS IN "LATENT" CASES1. Ann Intern Med. 1953;38:470–477. doi: 10.7326/0003-4819-38-3-470
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Published: Ann Intern Med. 1953;38(3):470-477.
Acute Coronary Syndromes, Cardiac Diagnosis and Imaging, Cardiology, Coronary Heart Disease, Emergency Medicine.
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