H. J. L. M.
When a clinical syndrome indicates involvement of several systems, the diagnostician thinks of disease processes with a widespread common denominator. The blood and blood vessels permeate every organ in the body; the lymphatic system is widespread; the endocrines, by virtue of their hormones, have far-reaching effects; metabolism is universal; connective tissue is common to all organs and systems; infectious agents can take root far and wide. The clinician therefore considers:
(1) blood diseases, such as leukemia, polycythemia, multiple myeloma, sickle cell anemia;
(2) vascular diseases, such as atherosclerosis, thromboangiitis obliterans, thrombophlebitis migrans;
(3) lymphomatous diseases, such as Hodgkin's disease, lymphosarcoma,
M. HJL. PRIMARY SYSTEMIC AMYLOIDOSIS. Ann Intern Med. ;38:620–626. doi: 10.7326/0003-4819-38-3-620
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Published: Ann Intern Med. 1953;38(3):620-626.
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