EUGENE G. LAFORET, M.D.
The elucidation of the rôle played by renal ischemia in the pathogenesis of hypertension by Goldblatt's now classic experiments1, 2, 3 has constituted one of the most significant recent advances in this field. With the accumulation of such distinct experimental evidence it was natural that efforts should follow to determine the possible relationship of renal ischemia to clinical hypertension as seen in man.4 In general, such studies have indicated that only in relatively isolated instances can a Goldblatt mechanism be definitely incriminated. The difficulties and hazards inherent in translating experimental data to clinical medicine are magnified when the problem is
LAFORET EG. MALIGNANT HYPERTENSION ASSOCIATED WITH UNILATERAL RENAL ARTERY OCCLUSION: THREE CASES1. Ann Intern Med. ;38:667–688. doi: 10.7326/0003-4819-38-4-667
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Published: Ann Intern Med. 1953;38(4):667-688.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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