C. J. D. ZAKAFONETIS, M.D., F.A.C.P.
Infectious mononucleosis and syphilis are notable for their widely varied clinical manifestations. It is also recognized that the differential diagnosis between these conditions may be very difficult under certain circumstances. This is readily apparent when it is recalled that malaise, lassitude, headache, myalgia, fever, sore throat, generalized lymphadenopathy and skin rash are features common to infectious mononucleosis and secondary syphilis. Fortunately, differentiation is usually possible through the use of appropriate laboratory studies. These include repeated examinations of the blood for the appearance of the leukocyte changes associated with infectious mononucleosis, and serial heterophil agglutination tests to detect agglutinins for sheep
ZAKAFONETIS CJD. OCCURRENCE OF INFECTIOUS MONONUCLEOSIS AND SYPHILIS IN THE SAME INDIVIDUAL12. Ann Intern Med. ;38:1053–1057. doi: 10.7326/0003-4819-38-5-1053
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Published: Ann Intern Med. 1953;38(5):1053-1057.
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