JOSEPH K. DORAN, M.D.; AUSTIN S. WEISBERGER, M.D.
Infectious mononucleosis is usually a benign, self-limited disease of unknown etiology, requiring only symptomatic therapy. Occasionally, serious complications such as hepatitis, thrombocytopenia, myocarditis, central nervous system involvement and splenic rupture may develop. Several fatal cases have been described, with death due to splenic rupture or to central nervous system involvement.1, 2 Attempts to modify the course of the disease with sulfonamides,3 penicillin,3 aureomycin4, 5 or chloramphenicol3 have been unsuccessful. In view of the pathologic findings of widespread involvement of almost every organ in the body by perivascular infiltration of normal and abnormal lymphocytes with enlargement of the lymph nodes and
DORAN JK, WEISBERGER AS. THE USE OF ACTH IN INFECTIOUS MONONUCLEOSIS1. Ann Intern Med. ;38:1058–1062. doi: 10.7326/0003-4819-38-5-1058
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Published: Ann Intern Med. 1953;38(5):1058-1062.
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