THOMAS A. WARTHIN, M.D., F.A.C.P.; EDWIN W. PETERSON, M.D.; JAMES H. BARR JR., M.D.
Idiopathic hemochromatosis is a metabolic disorder of iron metabolism, frequently familial, and probably the result of a faulty control of the ferritin absorptive mechanism in the small intestine. This excessive absorption, combined with the body's inability to excrete significant amounts of iron, results in the deposition of excessive amounts of hemosiderin in the body. Usually 25 gm. of iron, accumulating over a period of years, are necessary to produce the tissue damage which results in the clinical picture of bronzed diabetes. The disease is characteristically seen in middle aged males who present a disorder of cirrhosis, diabetes and hypogonadism, associated
WARTHIN TA, PETERSON EW, BARR JH. THE TREATMENT OF IDIOPATHIC HEMOCHROMATOSIS BY REPEATED PHLEBOTOMY1. Ann Intern Med. ;38:1066–1069. doi: 10.7326/0003-4819-38-5-1066
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Published: Ann Intern Med. 1953;38(5):1066-1069.
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