ALFRED S. EVANS; HELMUTH SPRINZ; ROBERT S. NELSON
In the preceding paper1 it has been shown that administration of adrenocorticotropic hormone (ACTH) to 20 patients with acute viral hepatitis was associated with symptomatic improvement and a rapid initial drop in serum bilirubin as compared with control patients. This effect on bilirubinemia became progressively less marked as the drug was continued. The eosinophil response was, in general, poor. The average total duration of illness was not materially affected. It seemed possible that adrenal cortical exhaustion was responsible in part for these phenomena, and that direct substitution therapy with cortisone might be more effective and at the same time lessen
EVANS AS, SPRINZ H, NELSON RS. ADRENAL HORMONE THERAPY IN VIRAL HEPATITIS. II. THE EFFECT OF CORTISONE IN THE ACUTE DISEASE1. Ann Intern Med. ;38:1134–1147. doi: 10.7326/0003-4819-38-6-1134
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Published: Ann Intern Med. 1953;38(6):1134-1147.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Viral Hepatitis.
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