FRANCIS D. MURPHY, M.D., F.A.C.P.; ALBINO L. SETTIMI, M.D.; NORMAN J. KOZOKOFF, M.D.
Chronic renal insufficiency produced by any progressive disease of the kidney may be associated with a variety of complications. Traditionally, it is known that diseased kidneys fail to excrete nitrogenous substances, and that this retention leads to azotemia and uremia. While the retention of salt and water by the kidney is considered the main cause of edema, any progressive kidney disease, whether polycystic kidney, chronic glomerulonephritis, tuberculosis of the kidney or pyelonephritis, may become associated not only with retention but also with excessive depletion of certain essential substances.
For some years the significance of abnormally low serum electrolytes has been
MURPHY FD, SETTIMI AL, KOZOKOFF NJ. RENAL DISEASE WITH THE SALT LOSING SYNDROME: A REPORT OF FOUR CASES OF SO-CALLED "SALT LOSING NEPHRITIS"1. Ann Intern Med. ;38:1160–1176. doi: 10.7326/0003-4819-38-6-1160
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Published: Ann Intern Med. 1953;38(6):1160-1176.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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