H. F. FRASER, M.D.; M. R. SHAVER, M.D.; E. S. MAXWELL, M.D.; H. ISBELL, M.D., F.A.C.P.
Although it is known that abrupt withdrawal of barbiturates from persons who have been chronically intoxicated with large amounts of these drugs may precipitate a serious abstinence syndrome,1, 2 a review of the American literature revealed no report in which death was attributed to abstinence from barbiturates. Three cases in which death was associated with withdrawal of barbiturates were found in the German literature. Two of these cases were complicated by the presence of organic disease (Buerger's disease with gangrene, and acute yellow atrophy of the liver with blood dyscrasia), so that abstinence from barbiturates could be regarded only as
FRASER HF, SHAVER MR, MAXWELL ES, ISBELL H. DEATH DUE TO WITHDRAWAL OF BARBITURATES1. Ann Intern Med. ;38:1319–1325. doi: 10.7326/0003-4819-38-6-1319
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Published: Ann Intern Med. 1953;38(6):1319-1325.
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