LEON LEWIS, M.D., F.A.C.P.; ROBERT F. ROBINSON, M.D.; JAMES YEE, M.D.; LUCY A. HACKER, M.D.; GEORGE EISEN, M.D.
When hyperadrenocorticism is deliberately induced with ACTH or cortisone for the control of disease, the resulting changes in disease activity are accompanied by a wide variety of physiologic and metabolic changes, some desirable and others unfavorable. Among these are alterations in the function of the anterior pituitary and the adrenal cortex, two endocrine glands of major importance in maintaining the ability of the body to withstand many different types of stress. The increased blood glycocorticoid level which cortisone induces directly and which ACTH produces by adrenal stimulation leads to an inhibition of the output of endogenous ACTH by the
LEWIS L, ROBINSON RF, YEE J, HACKER LA, EISEN G. FATAL ADRENAL CORTICAL INSUFFICIENCY PRECIPITATED BY SURGERY DURING PROLONGED CONTINUOUS CORTISONE TREATMENT1. Ann Intern Med. ;39:116–126. doi: 10.7326/0003-4819-39-1-116
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Published: Ann Intern Med. 1953;39(1):116-126.
Adrenal Disorders, Endocrine and Metabolism.
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