JAMES H. HUTCHINSON, M.D.; ROY A. HOWELL, M.D.
In 1947 Lerner and Watson1 suggested the term "cryoglobulinemia" to describe the presence of a cold precipitable protein in the serum. Three years later Barr, Reader and Wheeler2 reviewed the literature and found eight cases in which significant amounts of cryoglobulin had been observed; to these they added two of their own. Three additional cases have recently been recorded.3, 4, 5
In the case reported here, cold precipitable globulins were demonstrated in association with Raynaud's phenomena which progressed to gangrene and required multiple amputations. To our knowledge this is the first instance in which gangrene has been associated with cryoglobulinemia.
HUTCHINSON JH, HOWELL RA. CRYOGLOBULINEMIA: REPORT OF A CASE ASSOCIATED WITH GANGRENE OF THE DIGITS1. Ann Intern Med. ;39:350–357. doi: 10.7326/0003-4819-39-2-350
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Published: Ann Intern Med. 1953;39(2):350-357.
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