W. D. DAVIS JR., M.D., F.A.C.P.; W. R. ARROWSMITH, M.D.
Hemochromatosis is a rare disease characterized clinically by the triad of cirrhosis, diabetes and bronzing of the skin. The pathologic picture is one of massive accumulation of iron pigment throughout the tissues, with particular concentration in the epithelial glands and especially the liver and pancreas.1 The lymph nodes, heart, adrenals and testes are also frequently involved. The clinical course and gross and microscopic pathologic characteristics are well known.
The etiology and pathologic physiology are far less factually established, although recent investigations have yielded fairly convincing evidence as to its pathogenesis. Contrary to earlier conclusions,2 there is now sound evidence that
DAVIS WD, ARROWSMITH WR. THE TREATMENT OF HEMOCHROMATOSIS BY MASSIVE VENESECTION1. Ann Intern Med. ;39:723–734. doi: 10.7326/0003-4819-39-4-723
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Published: Ann Intern Med. 1953;39(4):723-734.
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