ALBERT G. GOLDIN, M.D.; KARL C. KELTY, M.D.; MARION F. BEARD, M.D., F.A.C.P.
Since Herrick's description of sickle cell anemia in 19101 the literature on this disease has been abundant, with the result that its natural course is fairly well documented. Termination ordinarily occurs before middle age, death usually resulting from intercurrent infections, sickle cell crises, cardiac failure, or hemorrhage or infarction of the brain, as well as from transfusion reactions incident to therapy.2, 3
The finding of leukemoid reaction is not uncommon in various hemolytic anemias,4, 5 including sickle cell anemia. The difficulty in differentiating some leukemoid reactions from acute leukemia has been pointed out by nearly all writers on the subject.
GOLDIN AG, KELTY KC, BEARD MF. SICKLE CELL ANEMIA TERMINATING IN ACUTE MYELOBLASTIC LEUKEMIA1. Ann Intern Med. ;39:920–928. doi: 10.7326/0003-4819-39-4-920
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Published: Ann Intern Med. 1953;39(4):920-928.
Hematology/Oncology, Red Cell Disorders.
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