ALEXANDER B. GUTMAN, M.D., F.A.C.P.
There is now some indication that the clinical syndrome of gout may well comprise several distinct anomalies of purine metabolism.1 Of these at least one may properly be considered a primary form of gout, the others as secondary to some other disease, usually involving the hematopoietic system.
Primary gout is the common category of the disorder, and is more widespread than is often appreciated. As suspected by Garrod,2 gout (in its primary form) may be classified as an inborn error of purine metabolism.3 Recent surveys4-6 of asymptomatic members of the families of patients with overt gout have revealed so high
GUTMAN AB. PRIMARY AND SECONDARY GOUT1. Ann Intern Med. ;39:1062–1076. doi: 10.7326/0003-4819-39-5-1062
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Published: Ann Intern Med. 1953;39(5):1062-1076.
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