JOSEPH F. URICCHIO, M.D.; DANIEL G. CALENDA, M.D.
The appearance of hyponatremia and edema in a patient with congestive heart failure represents a serious disturbance of electrolyte equilibrium. This disorder may develop quite insidiously or it may be acute in onset. The latter state, often referred to as the low salt syndrome, is accompanied in the majority of cases by mental aberrations, anorexia, nausea, vomiting, abdominal cramps, nitrogen retention and usually peripheral vascular collapse. On the other hand, chronic dilution hyponatremia is not associated with the usual signs and symptoms observed in patients with the acute depletion syndrome.1 The exact mechanism that leads to the production of a
URICCHIO JF, CALENDA DG. THE FAILURE OF HYPERTONIC SALINE IN THE TREATMENT OF HYPONATREMIA AND EDEMA IN CONGESTIVE HEART FAILURE1. Ann Intern Med. 1953;39:1288–1294. doi: 10.7326/0003-4819-39-6-1288
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Published: Ann Intern Med. 1953;39(6):1288-1294.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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