MAURICE SONES, M.D., F.A.C.P.; HAROLD L. ISRAEL, M.D., F.A.C.P.
It is widely accepted that in patients with sarcoidosis tuberculin sensitivity is infrequent or is of a low level and transient in nature. The mechanism responsible for the absence or loss of tuberculin sensitivity in these patients is not known. The suggestion1 that the low incidence of tuberculin reactions in sarcoidosis is merely the result of residence in areas of low tuberculosis morbidity is not valid, for it has been shown that patients with sarcoidosis fail to develop tuberculin sensitivity following repeated injections of BCG vaccine.2
The diminished sensitivity to tuberculin observed in patients with sarcoidosis has been attributed to
SONES M, ISRAEL HL. ALTERED IMMUNOLOGIC REACTIONS IN SARCOIDOSIS1. Ann Intern Med. ;40:260–268. doi: 10.7326/0003-4819-40-2-260
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Published: Ann Intern Med. 1954;40(2):260-268.
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