E. E. MUIRHEAD, M.D.; W. F. SHIELDS, M.D.
The occurrence of erythrophagocytosis and hemosiderosis in reticuloendothelial structures in association with the anemia of uremia of experimental animals1, 2, 3 suggested the need to determine whether such alterations occur in human tissues in association with bilateral renal disease causing renal failure and anemia. Such a study is reported below.
Twenty-eight cases of uremia without selection were studied. Abdominal and thoracic lymph nodes, spleen and liver were examined microscopically after staining with hematoxylin and eosin and iron stains. The morphologic changes in lymph nodes, spleen and liver searched for included hemorrhages in the peripheral and medullary sinuses
MUIRHEAD EE, SHIELDS WF. ERYTHROPHAGOCYTOSIS AND HEMOSIDEROSIS IN LYMPH NODES, SPLEEN AND LIVER IN PATIENTS DYING OF MALIGNANT HYPERTENSION, CHRONIC GLOMERULONEPHRITIS AND PYELONEPHRITIS AND POLYCYSTIC DISEASE1. Ann Intern Med. ;40:307–312. doi: 10.7326/0003-4819-40-2-307
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Published: Ann Intern Med. 1954;40(2):307-312.
Cardiology, Coronary Risk Factors, Gastroenterology/Hepatology, Hypertension, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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