MILTON S. SACKS, M.D.
Since 1948 three substances have been available to the clinician for the treatment of megaloblastic anemias. These three, all members of the vitamin B complex, are folic acid, citrovorum factor (folinic acid), and vitamin B12 (cyanocobalamin). Studies of their interrelationship have not only cast new light on the pathogenesis of pernicious anemia, but also permit further insight into the complexities of nucleoprotein metabolism. Although much remains to be elucidated, a brief resumé of some significant recent contributions may be of interest.
With the exception of rare cases of refractory megaloblastic anemia (achrestic anemia) all other megaloblastic anemias respond favorably, either
SACKS MS. VITAMIN B12 AND MEGALOBLASTIC ANEMIA: RECENT STUDIES. Ann Intern Med. 1954;40:375–380. doi: 10.7326/0003-4819-40-2-375
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Published: Ann Intern Med. 1954;40(2):375-380.
Hematology/Oncology, Red Cell Disorders.
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