J. A. HERSCHFUS, M.D.; A. SALOMON, M.D.; M. S. SEGAL, M.D., F.A.C.P.
Soon after the discovery of a new group of analgesic compounds in 1939,1 one of these, 1-methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride, was intensively investigated. This drug is generally known under the name of Demerol, meperidine, Dolantin, Pethidine or Isonipecaine, and its chemical structure is shown in figure 1.
Pharmacologic investigations showed that Demerol has a weak atropine-like and a stronger papaverine-like action on smooth muscle2; these actions were demonstrable on spastic or stimulated smooth muscle. Schaumann1, 3 also demonstrated spasmolytic action on intestinal or bronchial smooth muscle whether contraction was caused by a cholinergic drug, by nerve stimulation or by
HERSCHFUS JA, SALOMON A, SEGAL MS. THE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMA1. Ann Intern Med. ;40:506–515. doi: 10.7326/0003-4819-40-3-506
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Published: Ann Intern Med. 1954;40(3):506-515.
Asthma, Pulmonary/Critical Care.
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