R. S. DÍAZ-RIVERA, M.D., F.A.C.P.; FRANCISCO TRILLA, M.D.; EDUARDO R. PONS JR., M.D.
Among the most important problems in the management of generalized tetanus are the following: the muscle rigidity, generalized muscle spasms and convulsions, causing death from severe exhaustion; respiratory failure from muscular paralysis; asphyxia from too frequent or too long maintained laryngeal spasms, and anoxemia due to obstruction of the respiratory passages. The use of d-tubocurarine chloride is fraught with danger, because almost complete curarization is required for the control of muscle spasms. Also, the effects are transitory and unpredictable, and severe respiratory depression and tracheal obstruction are at times unavoidable.1 With the advent of 3 orthotoloxy-1, 2-propanediol (Mephenesin), favorable reports
DÍAZ-RIVERA RS, TRILLA F, PONS ER. MUSCULAR RELAXATION IN TETANUS WITH SPECIAL REFERENCE TO THE EFFECT OF MEPHENESIN1. Ann Intern Med. ;40:563–580. doi: 10.7326/0003-4819-40-3-563
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Published: Ann Intern Med. 1954;40(3):563-580.
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