LEO H. T. BERNSTEIN, M.D., Ph.D.; JOHN M. EVANS, M.D.
The use of ion exchange resins was suggested by Segal et al.2 for control of gastric acidity and by Dock3 for treatment of cardiac edema. The background and theory of ion exchange by resins in vitro and in vivo have been well elucidated.1, 4-22 In some 250 reported cases of edema of chronic cardiac decompensation,23-37 hepatic cirrhosis,27-38, 40 pregnancy39 and nephrosis,41, 42 a large proportion responded well to resin therapy. Some of the patients have received continuous resin medication for as long as a year. The daily dietary intake of sodium varied from 0.2 gm. up to 8.0 gm. and
BERNSTEIN LHT, EVANS JM. TREATMENT OF EDEMA WITH CATION EXCHANGE RESINS, INCLUDING CERTAIN HORMONAL OBSERVATIONS1. Ann Intern Med. ;40:698–710. doi: 10.7326/0003-4819-40-4-698
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Published: Ann Intern Med. 1954;40(4):698-710.
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